U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Lung adenoma

MedGen UID:
83394
•Concept ID:
C0345964
•
Neoplastic Process
Synonyms: Adenoma of lung; Adenoma of Lung; adenoma of lung; Adenoma of the Lung; adenoma of the lung; Lung Adenoma; lung adenoma; Pulmonary Adenoma; pulmonary adenoma
SNOMED CT: Adenoma of lung (254642004)
 
Monarch Initiative: MONDO:0003422

Definition

A benign, well circumscribed epithelial neoplasm that arises from the bronchus or the lung parenchyma. Representative examples include alveolar adenoma, papillary adenoma, and mucus gland adenoma. [from NCI]

Professional guidelines

PubMed

Chinese expert consensus on the diagnosis and treatment of malignant pleural mesothelioma.
Wang Q, Xu C, Wang W, Zhang Y, Li Z, Song Z, Wang J, Yu J, Liu J, Zhang S, Cai X, Li W, Zhan P, Liu H, Lv T, Miao L, Min L, Li J, Liu B, Yuan J, Jiang Z, Lin G, Chen X, Pu X, Rao C, Lv D, Yu Z, Li X, Tang C, Zhou C, Zhang J, Guo H, Chu Q, Meng R, Liu X, Wu J, Hu X, Zhou J, Zhu Z, Chen X, Pan W, Pang F, Zhang W, Jian Q, Wang K, Wang L, Zhu Y, Yang G, Lin X, Cai J, Feng H, Wang L, Du Y, Yao W, Shi X, Niu X, Yuan D, Yao Y, Huang J, Wang X, Zhang Y, Sun P, Wang H, Ye M, Wang D, Wang Z, Hao Y, Wang Z, Wan B, Lv D, Yu J, Kang J, Zhang J, Zhang C, Wu L, Shi L, Ye L, Wang G, Wang Y, Gao F, Huang J, Wang G, Wei J, Huang L, Li B, Zhang Z, Li Z, Liu Y, Li Y, Liu Z, Yang N, Wu L, Wang Q, Huang W, Hong Z, Wang G, Qu F, Fang M, Fang Y, Zhu X, Du K, Ji J, Shen Y, Chen J, Zhang Y, Ma S, Lu Y, Song Y, Liu A, Zhong W, Fang W
Thorac Cancer 2023 Sep;14(26):2715-2731. Epub 2023 Jul 17 doi: 10.1111/1759-7714.15022. PMID: 37461124Free PMC Article
Update on the clinical management of multiple endocrine neoplasia type 1.
Pieterman CRC, Valk GD
Clin Endocrinol (Oxf) 2022 Oct;97(4):409-423. Epub 2022 Apr 1 doi: 10.1111/cen.14727. PMID: 35319130Free PMC Article
Malignant pleural mesothelioma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up(☆).
Popat S, Baas P, Faivre-Finn C, Girard N, Nicholson AG, Nowak AK, Opitz I, Scherpereel A, Reck M; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2022 Feb;33(2):129-142. Epub 2021 Nov 30 doi: 10.1016/j.annonc.2021.11.005. PMID: 34861373

Recent clinical studies

Etiology

Optimized Bexarotene Aerosol Formulation Inhibits Major Subtypes of Lung Cancer in Mice.
Zhang Q, Lee SB, Chen X, Stevenson ME, Pan J, Xiong D, Zhou Y, Miller MS, Lubet RA, Wang Y, Mirza SP, You M
Nano Lett 2019 Apr 10;19(4):2231-2242. Epub 2019 Mar 21 doi: 10.1021/acs.nanolett.8b04309. PMID: 30873838
Early and delayed intervention with rapamycin prevents NNK-induced lung adenocarcinoma in A/J mice.
Patlolla JM, Kopelovich L, Qian L, Zhang Y, Kumar G, Madka V, Mohammed A, Biddick L, Sadeghi M, Lightfoot S, Rao CV
Oncol Rep 2015 Dec;34(6):2925-34. Epub 2015 Sep 16 doi: 10.3892/or.2015.4277. PMID: 26397133Free PMC Article
β-Escin inhibits NNK-induced lung adenocarcinoma and ALDH1A1 and RhoA/Rock expression in A/J mice and growth of H460 human lung cancer cells.
Patlolla JM, Qian L, Biddick L, Zhang Y, Desai D, Amin S, Lightfoot S, Rao CV
Cancer Prev Res (Phila) 2013 Oct;6(10):1140-9. Epub 2013 Aug 20 doi: 10.1158/1940-6207.CAPR-13-0216. PMID: 23963803
Senescence and pre-malignancy: how do tumors progress?
Saab R
Semin Cancer Biol 2011 Dec;21(6):385-91. Epub 2011 Oct 1 doi: 10.1016/j.semcancer.2011.09.013. PMID: 21982725
Anticarcinogenic effect of Panax ginseng C.A. Meyer and identification of active compounds.
Yun TK, Lee YS, Lee YH, Kim SI, Yun HY
J Korean Med Sci 2001 Dec;16 Suppl(Suppl):S6-18. doi: 10.3346/jkms.2001.16.S.S6. PMID: 11748383Free PMC Article

Diagnosis

An Evaluation of the Human Relevance of the Lung Tumors Observed in Female Mice Treated With Permethrin Based on Mode of Action.
Yamada T, Kondo M, Miyata K, Ogata K, Kushida M, Sumida K, Kawamura S, Osimitz TG, Lake BG, Cohen SM
Toxicol Sci 2017 Jun 1;157(2):465-486. doi: 10.1093/toxsci/kfx066. PMID: 28431163
beta-carotene-induced changes in RARbeta isoform mRNA expression patterns do not influence lung adenoma multiplicity in the NNK-initiated A/J mouse model.
Goralczyk R, Bachmann H, Wertz K, Lenz B, Riss G, Buchwald Hunziker P, Greatrix B, Aebischer CP
Nutr Cancer 2006;54(2):252-62. doi: 10.1207/s15327914nc5402_12. PMID: 16898870
Induction of urogenital anomalies and some tumors in the progeny of mice receiving diethylstilbestrol during pregnancy.
Nomura T, Kanzaki T
Cancer Res 1977 Apr;37(4):1099-104. PMID: 14781

Therapy

Statins mediate anti- and pro-tumourigenic functions by remodelling the tumour microenvironment.
Kamata T, Al Dujaily E, Alhamad S, So TY, Margaritaki O, Giblett S, Pringle JH, Le Quesne J, Pritchard C
Dis Model Mech 2022 Feb 1;15(2) Epub 2022 Jan 4 doi: 10.1242/dmm.049148. PMID: 34779486Free PMC Article
Optimized Bexarotene Aerosol Formulation Inhibits Major Subtypes of Lung Cancer in Mice.
Zhang Q, Lee SB, Chen X, Stevenson ME, Pan J, Xiong D, Zhou Y, Miller MS, Lubet RA, Wang Y, Mirza SP, You M
Nano Lett 2019 Apr 10;19(4):2231-2242. Epub 2019 Mar 21 doi: 10.1021/acs.nanolett.8b04309. PMID: 30873838
Chemosensitizing effect of shRNA-mediated ERCC1 silencing on a Xuanwei lung adenocarcinoma cell line and its clinical significance.
Wang W, Zhang L, Liu L, Zheng Y, Zhang Y, Yang S, Shi R, Wang S
Oncol Rep 2017 Apr;37(4):1989-1997. Epub 2017 Feb 14 doi: 10.3892/or.2017.5443. PMID: 28260069Free PMC Article
Early and delayed intervention with rapamycin prevents NNK-induced lung adenocarcinoma in A/J mice.
Patlolla JM, Kopelovich L, Qian L, Zhang Y, Kumar G, Madka V, Mohammed A, Biddick L, Sadeghi M, Lightfoot S, Rao CV
Oncol Rep 2015 Dec;34(6):2925-34. Epub 2015 Sep 16 doi: 10.3892/or.2015.4277. PMID: 26397133Free PMC Article
β-Escin inhibits NNK-induced lung adenocarcinoma and ALDH1A1 and RhoA/Rock expression in A/J mice and growth of H460 human lung cancer cells.
Patlolla JM, Qian L, Biddick L, Zhang Y, Desai D, Amin S, Lightfoot S, Rao CV
Cancer Prev Res (Phila) 2013 Oct;6(10):1140-9. Epub 2013 Aug 20 doi: 10.1158/1940-6207.CAPR-13-0216. PMID: 23963803

Prognosis

Smoking-associated Downregulation of FILIP1L Enhances Lung Adenocarcinoma Progression Through Mucin Production, Inflammation, and Fibrosis.
Kwon M, Rubio G, Wang H, Riedlinger G, Adem A, Zhong H, Slegowski D, Post-Zwicker L, Chidananda A, Schrump DS, Pine SR, Libutti SK
Cancer Res Commun 2022 Oct;2(10):1197-1213. Epub 2022 Oct 18 doi: 10.1158/2767-9764.CRC-22-0233. PMID: 36860703Free PMC Article
An Evaluation of the Human Relevance of the Lung Tumors Observed in Female Mice Treated With Permethrin Based on Mode of Action.
Yamada T, Kondo M, Miyata K, Ogata K, Kushida M, Sumida K, Kawamura S, Osimitz TG, Lake BG, Cohen SM
Toxicol Sci 2017 Jun 1;157(2):465-486. doi: 10.1093/toxsci/kfx066. PMID: 28431163
Chemosensitizing effect of shRNA-mediated ERCC1 silencing on a Xuanwei lung adenocarcinoma cell line and its clinical significance.
Wang W, Zhang L, Liu L, Zheng Y, Zhang Y, Yang S, Shi R, Wang S
Oncol Rep 2017 Apr;37(4):1989-1997. Epub 2017 Feb 14 doi: 10.3892/or.2017.5443. PMID: 28260069Free PMC Article
Cooperation of tyrosine kinase receptor TrkB and epidermal growth factor receptor signaling enhances migration and dispersal of lung tumor cells.
Götz R, Sendtner M
PLoS One 2014;9(6):e100944. Epub 2014 Jun 24 doi: 10.1371/journal.pone.0100944. PMID: 24959744Free PMC Article
beta-carotene-induced changes in RARbeta isoform mRNA expression patterns do not influence lung adenoma multiplicity in the NNK-initiated A/J mouse model.
Goralczyk R, Bachmann H, Wertz K, Lenz B, Riss G, Buchwald Hunziker P, Greatrix B, Aebischer CP
Nutr Cancer 2006;54(2):252-62. doi: 10.1207/s15327914nc5402_12. PMID: 16898870

Clinical prediction guides

Potential Anti-tumor Properties of PDIA4 in Lung Adenocarcinoma.
Kim HJ, Kim DY
Anticancer Res 2024 Oct;44(10):4309-4315. doi: 10.21873/anticanres.17260. PMID: 39348977
Inflammatory and mitogenic signals drive interleukin 23 subunit alpha (IL23A) secretion independent of IL12B in intestinal epithelial cells.
Lim KS, Yong ZWE, Wang H, Tan TZ, Huang RY, Yamamoto D, Inaki N, Hazawa M, Wong RW, Oshima H, Oshima M, Ito Y, Voon DC
J Biol Chem 2020 May 8;295(19):6387-6400. Epub 2020 Mar 24 doi: 10.1074/jbc.RA120.012943. PMID: 32209656Free PMC Article
How do K-RAS-activated cells evade cellular defense mechanisms?
Lee YS, Bae SC
Oncogene 2016 Feb 18;35(7):827-32. Epub 2015 May 11 doi: 10.1038/onc.2015.153. PMID: 25961920Free PMC Article
Early and delayed intervention with rapamycin prevents NNK-induced lung adenocarcinoma in A/J mice.
Patlolla JM, Kopelovich L, Qian L, Zhang Y, Kumar G, Madka V, Mohammed A, Biddick L, Sadeghi M, Lightfoot S, Rao CV
Oncol Rep 2015 Dec;34(6):2925-34. Epub 2015 Sep 16 doi: 10.3892/or.2015.4277. PMID: 26397133Free PMC Article
Senescence and pre-malignancy: how do tumors progress?
Saab R
Semin Cancer Biol 2011 Dec;21(6):385-91. Epub 2011 Oct 1 doi: 10.1016/j.semcancer.2011.09.013. PMID: 21982725

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...